Lefamulin (Intravenous)
Medically reviewed by Drugs.com. Last updated on May 23, 2022.
Commonly used brand name(s)
In the U.S.
- Xenleta
Available Dosage Forms:
- Solution
Therapeutic Class: Antibiotic
Chemical Class: Pleuromutilin
Uses for lefamulin
Lefamulin injection is used to treat community-acquired bacterial pneumonia (CABP).
Lefamulin belongs to the class of medicines known as pleuromutilin antibiotics. It works by killing bacteria or preventing their growth. However, lefamulin will not work for colds, flu, or other virus infections.
Lefamulin is to be given only by or under the direct supervision of your doctor.
Before using lefamulin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lefamulin, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to lefamulin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of lefamulin injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lefamulin injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving lefamulin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using lefamulin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Dasatinib
- Dofetilide
- Dronedarone
- Ivabradine
- Levoketoconazole
- Pimavanserin
- Pimozide
- Quetiapine
- Quinidine
- Tacrolimus
- Vardenafil
Using lefamulin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acalabrutinib
- Acecainide
- Alfentanil
- Alfuzosin
- Amiodarone
- Amitriptyline
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asenapine
- Astemizole...