Lenvatinib
Generic name: lenvatinib [ len-VA-ti-nib ]
Brand names: Lenvima, Lenvima 8 mg daily-dose, Lenvima 20 mg daily-dose, Lenvima 12 mg daily-dose
Dosage form: oral capsule (10 mg; 12 mg daily-dose; 14 mg daily-dose; 18 mg daily-dose; 20 mg daily-dose; 24 mg daily-dose; 4 mg; 8 mg daily-dose)
Drug classes:Multikinase inhibitors, VEGF/VEGFR inhibitors
What is lenvatinib?
Lenvatinib is a kinase inhibitor used to treat certain types of cancer. Kinase inhibitors are enzyme inhibitors that blocks the action of one or more protein kinases.
Lenvatinib is used to treat thyroid cancer. It is usually given after radioactive iodine has been tried without success.
Lenvatinib is used together with everolimus (Afinitor) to treat advanced kidney cancer when other medicines have not been effective.
Lenvatinib is used together with pembrolizumab (Keytruda) to treat a certain type of endometrial cancer (a type of uterine cancer) that has progressed and cannot be removed with surgery or radiation.
Lenvatinib is also used to treat liver cancer that cannot be removed with surgery.
Warnings
Some people taking lenvatinib have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Get emergency medical help if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Call your doctor at once if you have signs of serious side effects, including: severe chest pain, shortness of breath, swelling in your ankles, numbness or weakness, confusion, severe headache, problems with speech or vision, seizure (convulsions), unusual bleeding, coughing up blood, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Before taking this medicine
To make sure lenvatinib is safe for you, tell your doctor if you have ever had:
long QT syndrome (in you or a family member);
heart disease, high blood pressure;
a heart attack, heart failure, stroke, or blood clot;
headaches or vision problems;
bleeding problems;
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