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Leucovorin
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Leucovorin

Generic name: leucovorin (oral) [ LOO-koe-VOR-in ]
Dosage form: oral tablet (10 mg; 15 mg; 25 mg; 5 mg)
Drug class:Antidotes

Medically reviewed by Drugs.com on Jul 29, 2021. Written by Cerner Multum.

What is leucovorin?

Leucovorin is a form of folic acid. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is present in many foods such as dried beans, peas, oranges, spinach, and others.

Leucovorin is used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. This includes methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others.

Leucovorin may also be used for purposes not listed in this medication guide.

Warnings

You should not take leucovorin if you have pernicious anemia or other types of anemia caused by a lack of vitamin B12.

Before taking this medicine

You should not take leucovorin if you have pernicious anemia or other types of anemia caused by a lack of vitamin B12.

If possible before you receive leucovorin, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • breathing problems; or

  • if you are dehydrated.

Also tell your doctor about all other medications you currently use. There are many other drugs t...