Aminocaproic Acid Oral Solution

Dosage form: oral solution
Drug class:Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com. Last updated on May 1, 2022.

Aminocaproic Acid Oral Solution Description

Aminocaproic acid is 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.

Its chemical structure is:

Aminocaproic acid, USP is white or almost white crystalline powder or colorless crystals. It is freely soluble in water, slightly soluble in methanol, practically insoluble in acetone, hexane, methylene dichloride, and isopropyl alcohol.

Aminocaproic Acid Oral Solution, USP for oral administration, contains 0.25 g/mL of aminocaproic acid, USP with methylparaben 0.20%, propylparaben 0.02%, edetate disodium 0.30% as preservatives and the following inactive ingredients: bitter blocker, citric acid anhydrous, raspberry flavor, saccharin sodium dihydrate, sorbitol solution, and purified water.

Aminocaproic Acid Oral Solution - Clinical Pharmacology

The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1). Mean ± SD peak plasma concentrations (164 ± 28 mcg/mL) were reached within 1.2 ± 0.45 hours.

After oral administration, the apparent volume of distribution was estimated to be 23.1 ± 6.6 L (mean ± SD). Correspondingly, the volume of distribution after intravenous administration has been reported to be 30.0 ± 8.2 L. After prolonged administration, aminocaproic acid has been found to distribute throughout extravascular and intravascular compartments of the body, penetrating human red blood cells as well as other tissue cells.

Renal excretion is the primary route of elimination. Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid. Renal clearance (116 mL/min) approximates endogenous creatinine clearance. The total body clearance is 169 mL/min. The terminal elimination half-life for aminocaproic acid is approximately 2 hours.