Lido-MP40

Generic name: methylprednisolone, lidocaine
Dosage form: injectable suspension

Lido-MP40 KIT

-------------------- MethylPREDNISoloneACETATE Injectable Suspension USP Single-Dose Vial --------------------

Not For Intravenous Use

0031

Rx only

Lido-MP40 Description

Methylprednisolone Acetate Injectable Suspension USP is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available as single-dose vials in two strengths: 40 mg/mL; 80 mg/mL.

Each mL of these preparations contains:

Methylprednisolone acetate USP ..... 40 mg ..... 80 mg

Polyethylene glycol 3350 .....29 mg .....28 mg

Myristyl-gamma-picolinium chloride.....0.195 mg .....0.189 mg

Sodium Chloride was added to adjust tonicity.

When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.

The pH of the finished product remains within the USP specified range (e.g., 3.0 to 7.0).

The chemical name for methylprednisolone acetate USP is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6α,11β). The structural formula is represented below:

C 24H 32O 6 M.W. 416.51

Methylprednisolone Acetate Injectable Suspension USP contains methylprednisolone acetate, USP which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate USP is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.

Lido-MP40 - Clinical Pharmacology

Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids.

Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt retaining properties, are used in replacement therapy in adrenocortical deficiency states. Their synthetic analogs are used primarily for their anti-inflammatory e...