Lisocabtagene maraleucel
Generic name: lisocabtagene maraleucel [ LIS-oh-KAB-ta-jeen-MAR-a-LOOsel ]
Brand name: Breyanzi
Dosage form: intravenous suspension (-)
Drug class:Miscellaneous antineoplastics
What is lisocabtagene maraleucel?
Lisocabtagene maraleucel is an immunotherapy medicine used to treat large B-cell lymphoma in adults. Lisocabtagene maraleucel is given after at least two other cancer treatments did not work or have stopped working.
Lisocabtagene maraleucel is made using white blood cells removed from blood that is drawn from your body through a vein.
Lisocabtagene maraleucel may also be used for purposes not listed in this medication guide.
Warnings
A common but serious side effect of lisocabtagene maraleucel is called cytokine release syndrome, which causes fever, chills, trouble breathing, vomiting, and other symptoms. Your caregivers will have medication available to quickly treat this condition if it occurs.
Before taking this medicine
Tell your doctor if you have ever had:
hepatitis B or C; or
if you have received a vaccine within the past 6 weeks.
Using lisocabtagene maraleucel may increase your risk of developing other cancers. Ask your doctor about this risk.
Tell your doctor if you are pregnant or breastfeeding.
You may need to have a negative pregnancy test before starting this treatment.
How is lisocabtagene maraleucel given?
Lisocabtagene maraleucel is available only at an authorized hospital or clinic, and must be given by specially trained healthcare professionals.
Lisocabtagene maraleucel is given after a procedure called leukapheresis (LOO-kuh-fuh-REE-sis).
During leukapheresis, some of your blood is collected through a small tube (catheter) placed into a vein. The catheter is connected to a machine that separates your white blood cells from other parts of the blood.
The cells are then sent to a laboratory where they are made into lisocabtagene maraleucel. Because it will take time to process your blood cells into lisocabtagene maraleucel, you will not receive the medicine on the same day your blood cells are drawn.
About 2 to 7 days before lisocabtagene maraleucel is given, you will be pre-treated with chemotherapy to help prepare your body for lisocabtagene maraleucel.
Once your body is ready to receive lisocabtagene maraleucel, your care providers will inject the medicine as an infusion into a vein.
You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
