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Amitriptyline
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Amitriptyline

Generic name: amitriptyline [ a-mee-TRIP-ti-leen ]
Brand names: Elavil, Endep, Vanatrip
Drug class:Tricyclic antidepressants

Medically reviewed by Sanjai Sinha, MD. Last updated on Sep 30, 2021.

What is amitriptyline?

Amitriptyline is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitriptyline is a prescription medicine used to treat symptoms of depression.

Amitriptyline may also be used for purposes not listed in this medication guide.

Warnings

You should not use amitriptyline if you have recently had a heart attack.

Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

You may have thoughts about suicide when you first start taking an antidepressant such as amitriptyline, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself...