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Amitriptyline and perphenazine
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Amitriptyline and perphenazine

Generic name: amitriptyline and perphenazine [ a-mee-TRIP-ti-leen-and-per-FEN-a-zeen ]
Brand names: Etrafon 2-10, Etrafon 2-25, Etrafon Forte, Triavil
Dosage form: oral tablet (10 mg-2 mg; 10 mg-4 mg; 25 mg-2 mg; 25 mg-4 mg; 50 mg-4 mg)
Drug class:Psychotherapeutic combinations

Medically reviewed by Drugs.com on May 26, 2022. Written by Cerner Multum.

What is amitriptyline and perphenazine?

Amitriptyline is a tricyclic antidepressant. Perphenazine is a phenothiazine (feen-oh-THYE-a-zeen).

Amitriptyline and perphenazine is a combination medicine used to treat depression, anxiety, and agitation.

Amitriptyline and perphenazine may also be used for purposes not listed in this medication guide.

Warnings

You should not take amitriptyline and perphenazine if you have if you recently had a heart attack, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. Amitriptyline and perphenazine is not approved for use in older adults with dementia-related psychosis.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Before taking this medicine

You should not use this medicine if you are allergic to amitriptyline or perphenazine, or if:

  • you have recently had a heart attack; or

  • you have recently used alcohol, sedatives, tranquilizers, or opioid medications.

This medicine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Do not use amitriptyline and perphenazine if you have used an MAO inhibitor in the past 14 days. A dangero...