Lumasiran Sodium
Class: Other Miscellaneous Therapeutic Agents
Brands: Oxlumo
Introduction
Lumasiran sodium is a HAO1-directed small interfering ribonucleic acid (siRNA).
Uses for Lumasiran Sodium
Lumasiran sodium has the following uses:
Lumasiran sodium is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels in pediatric and adult patients.
Lumasiran Sodium Dosage and Administration
General
Lumasiran sodium is available in the following dosage form(s) and strength(s):
Injection: 94.5 mg/0.5 mL in a single-dose vial.
Dosage
It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Pediatric Patients
Dosage and Administration
The recommended dose of lumasiran sodium by subcutaneous injection is based on body weight.
Body Weight | Loading Dose | Maintenance Dose (begin 1 month after the last loading dose) |
|---|---|---|
less than 10 kg | 6 mg/kg once monthly for 3 doses | 3 mg/kg once monthly |
10 kg to less than 20 kg | 6 mg/kg once monthly for 3 doses | 6 mg/kg once every 3 months (quarterly) |
20 kg and above | 3 mg/kg once monthly for 3 doses | 3 mg/kg once every 3 months (quarterly) |
See Full Prescribing Information for important preparation and administration instructions.
Adults
Dosage and Administration
The recommended dose of lumasiran sodium by subcutaneous injection is based on body weight.
Body Weight | Loading Dose | Maintenance Dose (begin 1 month after the last loading dose) |
|---|---|---|
less than 10 kg | 6 mg/kg once monthly for 3 doses | 3 mg/kg once monthly |
10 kg to less than 20 kg | 6 mg/kg once monthly for 3 doses | 6 mg/kg once every 3 months (quarterly) |
20 kg and above | 3 mg/kg once monthly for 3 doses | 3 mg/kg once every 3 months (quarterly) |
See Full Prescribing Information for important preparation and administration instructions.
Cautions for Lumasiran Sodium
Contraindications
None.
