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Amlodipine and Olmesartan Medoxomil
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  • FDA PI

Amlodipine and Olmesartan Medoxomil

Dosage form: tablet, film coated
Drug class:Angiotensin II inhibitors with calcium channel blockers

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

WARNING: FETAL TOXICITY
  • When pregnancy is detected, discontinue Amlodipine and Olmesartan Medoxomil tablets as soon as possible (5.1).
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.1).

Indications and Usage for Amlodipine and Olmesartan Medoxomil

Amlodipine and Olmesartan Medoxomil tablets are indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Amlodipine and Olmesartan Medoxomil tablets.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular m.