Lurbinectedin (Intravenous)
Medically reviewed by Drugs.com. Last updated on Apr 30, 2022.
Commonly used brand name(s)
In the U.S.
- Zepzelca
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Uses for lurbinectedin
Lurbinectedin injection is used to treat metastatic (cancer that has already spread) small cell lung cancer (SCLC) in patients who have received other cancer medicines (eg, platinum-based chemotherapy) that did not work well.
Lurbinectedin is to be given only by or under the direct supervision of your doctor.
Before using lurbinectedin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lurbinectedin, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to lurbinectedin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of lurbinectedin injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lurbinectedin injection in the elderly. However, elderly patients are more likely to have serious unwanted effects (eg, blood or bone marrow problems), which may require caution in patients receiving lurbinectedin.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving lurbinectedin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using lurbinectedin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Apalutamide
- Aprepitant
- Atazanavir
- Boceprevir
- Bosentan
- Carbamazepine
- Cenobamate
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Diltiazem
- Dronedarone
- Efavirenz
- Enzalutamide
- Erythromycin
- Etravirine
- Fedratinib
- Fexinidazole
- Fluconazole
- Fluvoxamine
- Fosnetupitant
- Fosphenytoin
- Idelalisib
- Imatinib
- Indinavir
- Itraconazole
