Luspatercept-aamt (Injection)

Medically reviewed by Drugs.com. Last updated on Apr 25, 2022.

Uses for luspatercept-aamt

Luspatercept-aamt injection is used to treat anemia in patients with beta thalassemia who need regular red blood cell (RBC) transfusions.

Luspatercept-aamt injection is also used to treat anemia in patients with myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need regular red blood cell (RBC) transfusions. Luspatercept-aamt is given to patients who cannot receive erythropoiesis stimulating agent (ESA) or has received ESA but did not work well.

Luspatercept-aamt is to be given only by or under the immediate supervision of your doctor.

Before using luspatercept-aamt

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For luspatercept-aamt, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to luspatercept-aamt or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of luspatercept-aamt injection in the pediatric population. Use in children is not recommended.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of luspatercept-aamt injection in the geriatric population.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of luspatercept-aamt. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood clots, history of or
• Hypertension (high blood pressure)—Use with caution. May make these conditions worse.

• Smoking or
• Splenectomy (surgery to remove the spleen), history of—May increase risk for more serious side effects.

Proper use of luspatercept-aamt

A doctor or other trained health professional will give you luspatercept-aamt in a hospital. It is...