Ammonium Molybdate Injection

Dosage form: injection, solution
Drug class:Minerals and electrolytes

Medically reviewed by Drugs.com. Last updated on Sep 21, 2021.

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STERILE, NONPYROGENIC

TRACE ELEMENT ADDITIVE

FOR IV USE AFTER DILUTION

Rx Only

Ammonium Molybdate Injection Description

Ammonium Molybdate Injection, USP is a sterile, nonpyrogenic solution for use as an additive to solutions for Total Parenteral Nutrition (TPN). Each mL contains Ammonium Molybdate Tetrahydrate (NH4)6MO7O24•4H2O, 46 mcg and Water for Injection q.s. Each mL provides 25 mcg of Molybdenum. Ammonium Hydroxide and/or Hydrochloric Acid may have been added to adjust pH.

Ammonium Molybdate Injection - Clinical Pharmacology

Molybdenum is a constituent of the enzymes xanthine oxidase, sulfite oxidase, and aldehyde oxidase. Among other reactions, xanthine oxidase catalyzes conversion of xanthine and hypoxanthine to uric acid; sulfite oxidase converts sulfite to sulfate; and aldehyde oxidase detoxifies a variety of harmful organic molecules (such as aldehydes into acids).

In humans, molybdenum deficiency resulting from prolonged TPN support has been reported in literature. The deficiency syndrome included tachycardia, tachypnea, headache, night blindness, nausea, vomiting, central scotomas, culminating in generalized edema, lethargy, disorientation, and coma. The biochemical changes associated with the syndrome were: hypermethioninemia, hypouricemia, hypouricosuria, low urinary excretion of inorganic sulfate and elevated urinary excretion of Thiosulfate. Supplementation of TPN solutions with Molybdenum has been reported to alleviate the symptoms and normalize the biochemical abnormalities.

In animals, diet induced molybdenum deficiency has been produced experimentally with tungstate. The deficiency symptoms are characterized by decreased weight gain, food consumption, and life expectancy and deranged microbiological processes in the rumen. Renal xanthine calculi have been reported in sheep grazing on low-molybdenum pasture.

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