MDP Utilipak
Generic name: Medronic acid
Dosage form: Injection
Drug class:Radiologic conjugating agents
Medically reviewed by Drugs.com. Last updated on Jul 22, 2021.
MDP MULTIDOSE UTILIPAK
Kit for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
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MDP Utilipak Description
Each kit contains 10 multidose reaction vials, each containing 30 mg of medronic acid, 0.51 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.87 mg), and 6 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of 6.02 hours.* The principal photon that is useful for detection and imaging studies is listed in Table 1.
| Radiation | Mean %/Disintegration | Mean Energy (keV) |
|---|---|---|
| ||
| Gamma-2 | 89.07 | 140.5 |
External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
