Medihaler-Iso
Generic name:isoproterenol sulfate
Dosage form: Inhalation Aerosol
Drug classes:Adrenergic bronchodilators, Catecholamines, Vasopressors
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
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PHARMACIST:
Tear off “Patient Instructions for Use” and dispense with product.
The Medihaler-Iso brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Medihaler-Iso Description
Medihaler-Iso (isoproterenol sulfate) is a short-acting sympathomimetic administered by oral inhalation for the treatment of bronchoconstriction. Each metered dose of the aerosol delivers through the oral adapter 0.08 mg isoproterenol sulfate of appropriate particle size (the majority less than 5μ). This drug product also contains dichlorodifluoromethane, dichlorotetrafluoroethane, sorbitan trioleate, and trichloromonofluoromethane. Chemically, isoproterenol sulfate is 4-[1-hyroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol sulfate.
Structural formula:
Medihaler-Iso - Clinical Pharmacology
Isoproterenol acts directly on beta-adrenergic receptors of tissues supplied by sympathetic nerves. The beta-adrenergic effects stem from the release of cyclic AMP following the activation of the enzyme adenyl cyclase. Therapeutic doses of isoproterenol result in relaxation of the smooth muscle of the bronchial tree and decrease in peripheral vascular resistance; increased cardiac output and stroke volume may occur due to its positive inotropic and chronotropic action. The coronary arteries may be dilated, increasing the blood flow. Isoproterenol also inhibits uterine motility and causes decreased tone and motility of intestinal musculature even when epinephrine causes contraction.
In patients with bronc...
