Amphadase (injection)

Generic name:hyaluronidase (injection) [ HYE-al-ure-ON-i-dase ]
Brand names: Amphadase, Hylenex, Vitrase
Drug class:Miscellaneous uncategorized agents

Medically reviewed by Drugs.com on Jun 6, 2022. Written by Cerner Multum.

What is hyaluronidase?

Hyaluronidase is a genetically designed protein.

Hyaluronidase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications.

Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Hyaluronidase may also be used for purposes not listed in this medication guide.

Warnings

Serious drug interactions can occur when certain medicines are used together with hyaluronidase. Tell your doctor about all your current medicines.

Before taking this medicine

You should not be treated with hyaluronidase if you are allergic to it.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may change your treatment plan if you also use:

• furosemide (Lasix);

• phenytoin (Dilantin);

• a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);

• aspirin or salicylates;

• cortisone or ACTH (Corticotropin);

• estrogens; or

• an antihistamine (such as a cold or allergy medicine).

Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is hyaluronidase given?

Hyaluronidase is injected under the skin, into a muscle, or i...