Methylergonovine (Injection)

Medically reviewed by Drugs.com. Last updated on Apr 26, 2022.

Commonly used brand name(s)

In the U.S.

• Methergine

Available Dosage Forms:

• Solution

Therapeutic Class: Uterine Stimulant

Chemical Class: Ergot Alkaloid

Uses for methylergonovine

Methylergonovine injection is used to prevent and control bleeding from the uterus that can happen after childbirth. It belongs to the class of medicines called ergot alkaloids. Methylergonovine works by acting directly on the smooth muscles of the uterus and prevents bleeding after giving birth.

Methylergonovine is to be given only by or under the direct supervision of a doctor.

Before using methylergonovine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For methylergonovine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to methylergonovine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of methylergonovine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of methylergonovine injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving methylergonovine injection.

Breastfeeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving methylergonovine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using methylergonovine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Almotriptan
• Amprenavir
• Atazanavir
• Azithromycin
• Boceprevir
• Clarithromycin
• Cobicistat
• Darunavir
• Delavirdine
• Dinoprostone
• Dirithromycin
• Eletriptan
• Erythromycin
• Fosamprenavir
• Frovatriptan
• Indinavir
• Itraconazole
• Josamycin
• Ketoconazole
• Letermovir
• Lopinavir
• Mepartricin
• Miokamycin
• Naratr...