Myocard-DX

Generic name:dopamine hydrochloride in dextrose
Dosage form: injection

Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.

Myocard-DX Description

Dopamine Hydrochloride in 5% Dextrose Injection USP is prepared from Dopamine Hydrochloride and Hydrous Dextrose USP in Water for Injection USP. These solutions are for intravenous use only.

These solutions are sterile, nonpyrogenic, isotonic, and contain no bacteriostatic or antimicrobial agents or added buffers. They are intended for single use only. When smaller doses are required, the unused portion should be discarded.

Each 100 mL contains dopamine hydrochloride 80 mg or 160 mg and dextrose, hydrous, 5 g in water for injection, with sodium metabisulfite added 50 mg as a stabilizer; osmolar concentration, respectively 270 and 275 mOsmol/liter, pH 3.3 (2.5 - 4.5). pH may be adjusted with Hydrochloric Acid NF or Sodium Hydroxide NF, as required.

Dopamine administered intravenously is a myocardial inotropic agent which also may increase mesenteric and renal blood flow plus urinary output.

Dopamine hydrochloride is designated chemically, as 3,4-dihydroxyphenethylamine hydrochloride, a white crystalline powder freely soluble in water. Dopamine (also referred to as 3-hydroxytyramine) is a naturally occurring biochemical catecholamine precursor of norepinephrine.

The formulas of the active ingredients are:

Ingredients	Molecular Formula	Molecular Weight
Hydrous Dextrose USP		198.17
Dopamine Hydrochloride		189.64

Myocard-DX - Clinical Pharmacology

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves.

Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate a...