Osilodrostat
Generic name: osilodrostat [ O-sil-OH-droe-stat ]
Brand name: Isturisa
Dosage form: oral tablet (1 mg; 10 mg; 5 mg)
Drug class:Adrenal corticosteroid inhibitors
What is osilodrostat?
Osilodrostat is used in adults to treat Cushing's disease that cannot be treated with pituitary surgery.
Osilodrostat may also be used for purposes not listed in this medication guide.
Warnings
Osilodrostat can cause serious side effects, such as heartbeat problems or decreased adrenal gland hormones. Call your doctor at once if you have irregular heartbeats, stomach pain, vomiting, loss of appetite, tiredness, or feeling light-headed.
Before taking this medicine
Tell your doctor if you have ever had:
a heart rhythm disorder;
long QT syndrome (in you or a family member);
congestive heart failure;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
fluid retention; or
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether osilodrostat will harm an unborn baby. However, having Cushing's disease during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating Cushing's disease may outweigh any risks to the baby.
Do not breastfeed while using osilodrostat, and for at least 1 week after your last dose.
Osilodrostat is not approved for use by anyone younger than 18 years old.
How should I take osilodrostat?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take osilodrostat with or without food.
Your doctor will check your heart function using an electrocardiograph or ECG (sometimes called an EKG). Your next dose may be delayed based on the results of your ECG or other medical tests.
Do not change your dose or dosing schedule without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
