Prascion FC Cleansing Cloths
Generic name:sodium sulfacetamide and sulfur
Dosage form: topical cloth
Drug class:Topical antibiotics
Medically reviewed by Drugs.com. Last updated on Jul 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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DESCRIPTION: Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically, sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]-acetamide, monosodium salt, monohydrate. The structural formula is:
Each cloth of Prascion® FC (sodium sulfacetamide USP 10% and sulfur USP 5%) Facial Cleansing Cloths is coated with a cleanser-based formulation. Each gram of this cleanser-based formulation contains 100 mg of sodium sulfacetamide USP and 50 mg of sulfur USP. The cleanser base consists of: butylated hydroxytoluene NF, cetyl alcohol NF, disodium oleamido MEA sulfosuccinate, edetate disodium USP, fragrance, glyceryl stearate/PEG-100 stearate, glycerin USP, methylparaben NF, propylparaben NF, purified water USP, sodium cocoyl isethionate, sodium lauryl sulfoacetate, sodium thiosulfate USP, stearyl alcohol NF.
CLINICAL PHARMACOLOGY: The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.
INDICATIONS: Prascion FC Facial Cleansing Cloths are indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.
