Sulfacetamide and Prednisolone

Generic name: sulfacetamide sodium and prednisolone sodium phosphate
Dosage form: ophthalmic solution
Drug class:Ophthalmic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

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Sulfacetamide and Prednisolone Description

Sulfacetamide Sodium and Prednisolone Sodium Phosphate Ophthalmic Solution is a sterile topical ophthalmic solution combining an anti-infective and an adrenocortical steroid.

Each mL contains: ACTIVES: Sulfacetamide Sodium 100 mg, Prednisolone Sodium Phosphate 2.5 mg (equivalent to Prednisolone Phosphate 2.3 mg); INACTIVES: Poloxamer 407, Boric Acid, Edetate Disodium, Purified Water. Hydrochloric Acid and/or Sodium Hydroxide may be added to adjust pH (6.5-7.5). PRESERVATIVE ADDED: Thimerosal 0.01%.

The chemical name for sulfacetamide sodium is N-sulfanilylacetamide monosodium salt monohydrate.

The chemical name for prednisolone sodium phosphate is 11β,17,21-trihydroxypregna-1, 4-diene-3,20-dione, 21-(disodium phosphate).

They have the following structural formulas:

Sulfacetamide Sodium

C8H9N2NaO3S•H2O Mol. Wt. 254.24

Prednisolone Sodium Phosphate

C21H27Na2O8P Mol. Wt. 484.39

Sulfacetamide and Prednisolone - Clinical Pharmacology

Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular ...