Dosage form: injection, powder, lyophilized, for solution
Drug class:Miscellaneous antibiotics
Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for injection and other antibacterial drugs, Aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Aztreonam Description
Aztreonam for Injection, USP contains the active ingredient Aztreonam, a monobactam. It was originally isolated from Chromobacterium violaceum. It is a synthetic bactericidal antibiotic.
The monobactams, having a unique monocyclic beta-lactam nucleus, are structurally different from other beta-lactam antibiotics (eg, penicillins, cephalosporins, cephamycins). The sulfonic acid substituent in the 1-position of the ring activates the beta-lactam moiety; an aminothiazolyl oxime side chain in the 3-position and a methyl group in the 4-position confer the specific antibacterial spectrum and beta-lactamase stability.
Aztreonam is designated chemically as (Z)-2-[[[(2-amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid.
Structural formula:
