Cobimetinib
Generic name: cobimetinib [ KOE-bi-ME-ti-nib ]
Brand name: Cotellic
Dosage form: oral tablet (20 mg)
Drug class:Multikinase inhibitors
What is cobimetinib?
Cobimetinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Cobimetinib is used to treat a certain type of metastatic melanoma (skin cancer) that has spread to other parts of the body and cannot be removed with surgery. Cobimetinib is usually given together with another medicine called vemurafenib (Zelboraf).
Cobimetinib is used only if your tumor has a specific genetic marker, for which your doctor will test.
Cobimetinib may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use cobimetinib if you are allergic to it.
To make sure cobimetinib is safe for you, tell your doctor if you have:
heart disease, heart rhythm disorder;
a history of eye problems (especially a problem with your retina);
liver or kidney disease;
skin problems not related to melanoma;
a muscle disorder;
a bleeding or blood clotting disorder such as hemophilia; or
a condition for which you take a blood thinner such as warfarin (Coumadin, Jantoven).
Using cobimetinib may increase your risk of developing other types of skin cancer. Ask your doctor about your specific risk.
Do not use cobimetinib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 2 weeks after your last dose.
It is not known whether cobimetinib passes into breast milk or if it could harm a nursing baby. Do not breast-feed while taking cobimetinib, and for 2 weeks after your last dose.
How should I take cobimetinib?
Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with cobimetinib.
Follow all directions on your prescription label. Do not use cobimetinib in larger or smaller amounts or for longer than recommended.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Cobimetinib is given in a 28-day treatment cycle. You may need to use the medicine only dur...
