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Cyclobenzaprine
  • Treatments
  • Muscle Spasm

Cyclobenzaprine

Generic name: cyclobenzaprine [ sye-kloe-BEN-za-preen ]
Brand names: Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril
Drug class:Skeletal muscle relaxants

Medically reviewed by Kaci Durbin, MD. Last updated on May 23, 2022.

What is cyclobenzaprine?

Cyclobenzaprine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Cyclobenzaprine may also be used for purposes not listed in this medication guide.

Warnings

You should not use cyclobenzaprine if you have an allergy to the medication, a certain type of thyroid disorder (hyperthyroidism), heart block, congestive heart failure, a heart rhythm disorder, or you have recently had a heart attack.

Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use cyclobenzaprine if you are allergic to it, or if you have:

  • hyperthyroidism;

  • heart block, heart rhythm disorder, congestive heart failure; or

  • if you have recently had a heart attack.

Cyclobenzaprine is not approved for use by anyone younger than 15 years old.

Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, sele...