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Denavir
  • Treatments
  • Cold Sores

Denavir Cream

Generic name:penciclovir topicalpen-SYE-kloe-veer-TOP-ik-al ]
Drug class:Topical antivirals

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 12, 2022.

What is Denavir?

Denavir is an antiviral medication.

Denavir is a prescription cream used to treat cold sores on the lips that are caused by the herpes simplex virus. This medicine is for adults and children who are at least 12 years old.

Denavir is not a cure for cold sores and you may continue to have them in the future.

Warnings

Do not apply the cream to the inside of the nose or in or near the eyes.

Before using this medicine

You should not use Denavir cream if you are allergic to penciclovir.

Since penciclovir topical (for the skin) is not absorbed into the body, using this medicine is not expected to be harmful if you are pregnant or breast-feeding.

Denavir cream is not approved for use by anyone younger than 12 years old.

How should I use Denavir cream?

Use Denavir exactly as directed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. Topical medicine is for use only on the lips and face. If this medicine gets in your nose or mouth, rinse with water.

Denavir should be used to treat cold sores on the lips and face only.

For best results, start using penciclovir as soon as possible after you notice symptoms of a developing cold sore (tingling, redness, itching, or a bump).

Wash your hands before and after applying Denavir cream. Also wash and dry the skin area to be treated.

Apply a thin layer of penciclovir to the cold sore area. Use enough medicine to cover only the cold sore itself, or the skin where you feel tingling or early symptoms of a developing cold sore. Rub in gently until the medicine disappears.

Do not apply Denavir cream to the inside of your nose or near your eyes.

Denavir cream is usually applied every 2 hours throughout the day for 4 days in a row. Follow your doctor's dosing instructions very carefully.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Herpes Simplex Labialis:

Apply cream to affected area every 2 hours while awake
Duration of therapy: 4 days

Comments: Treatment should begin as early as possible (i.e., during the prodrome or when lesions appear).

Use: For the treatment of recurrent herpes labialis (cold sores)

Usual Pediatric Dose for Herpes Simplex Labialis:

12 years or older: Apply cream to affected area every 2 hours while awake
Duration of therapy: 4 days

Comments: Treatment should begin as early as possible (i.e., during the prodrome