Goprelto
Generic name:cocaine hydrochloride
Dosage form: nasal solution
Drug class:Topical anesthetics
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
On This Page
- Boxed Warning
- Indications and Usage
- Dosage and Administration
- Dosage Forms and Strengths
- Contraindications
- Warnings and Precautions
- Adverse Reactions/Side Effects
- Drug Interactions
- Use In Specific Populations
- Drug Abuse and Dependence
- Overdosage
- Description
- Clinical Pharmacology
- Nonclinical Toxicology
- Clinical Studies
- How Supplied/Storage and Handling
- Patient Counseling Information
CNS stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence [see Warnings and Precautions (5.1).
Indications and Usage for Goprelto
Goprelto (cocaine hydrochloride) nasal solution is indicated for the induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities in adults.
Goprelto Dosage and Administration
Important Dosage and Administration Instructions
- Goprelto is for intranasal use only.
- Do not apply Goprelto to damaged nasal mucosa.
Dosing Recommendation for Adults
The recommended dose of Goprelto is two soaked cottonoid pledgets placed in each nasal cavity, equivalent to 40 mg cocaine hydrochloride per pledget, for a total dose of 160 mg for four pledgets.
The total dose for any one procedure or surgery should not exceed 160 mg, or 3 mg/kg, cocaine hydrochloride.
The recommended size of cottonoid pledgets for use with Goprelto measure 1.3 cm × 4 cm (sold separately).
Preparation and Administration of Goprelto Pledgets
Pour the full contents of one 4 mL (160 mg) bottle of Goprelto into a small container. Soak four cottonoid pledgets until the solution is fully absorbed.
Following soaking, place two pledgets in each nasal cavity against the septum.
Leave pledgets in place for up to twenty minutes. Remove pledgets and con...
