Imcivree

Generic name:setmelanotide
Dosage form: injection, for subcutaneous use
Drug class:Melanocortin receptor agonists

Medically reviewed by Judith Stewart, BPharm. Last updated on Jun 16, 2022.

What is Imcivree?

• Imcivree is a prescription medicine used in adults and children 6 years of age and older with obesity due to:
  • The genetic conditions proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, to help them lose weight and keep the weight off.
  • Bardet-Biedl syndrome (BBS) to help them lose weight and keep the weight off.
• Your healthcare provider should order a genetic test to confirm POMC, PCSK1, or LEPR deficiency before you start treatment.
• Imcivree is not for use in people with the following conditions because it may not work:
  • Obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing or with benign or likely benign testing results.
  • Other types of obesity not related to POMC, PCSK1, or LEPR deficiency, or BBS, including obesity associated with other genetic conditions and general obesity.

It is not known if this medicine is safe and effective in children under 6 years of age.

Before using Imcivree

Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

• have or have had areas of darkened skin, including skin discoloration (hyperpigmentation).
• have or have had depression, or suicidal thoughts or behavior.
• have kidney problems.
• are pregnant or planning to become pregnant. Losing weight while pregnant may harm your unborn baby. Your healthcare provider may stop your treatment if you become pregnant. Tell your healthcare provider if you become pregnant or think you might be pregnant during treatment.
• are breastfeeding or plan to breastfeed. It is not known if Imcivree passes into your breastmilk. Yo.