Ivosidenib
Generic name: ivosidenib [ EYE-voe-SID-e-nib ]
Brand name: Tibsovo
Dosage form: oral tablet (250 mg)
Drug class:Miscellaneous antineoplastics
What is ivosidenib?
Ivosidenib targets a specific gene mutation called IDH1, which can affect your bone marrow. IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in symptoms of acute myeloid leukemia (AML).
Ivosidenib is for use only in adults with an IDH1 mutation. Your doctor will test you for this gene.
Ivosidenib is used to treat AML after other treatments did not work or stopped working.
Ivosidenib is also used to treat AML in adults 75 years and older who have newly-diagnosed AML and cannot use certain chemotherapy treatments because of other health problems.
Ivosidenib is also used to treat bile duct cancer that has progressed or has spread to other parts of the body (metastatic) after treatment with other medicine.
Ivosidenib may also be used for purposes not listed in this medication guide.
Warnings
Ivosidenib can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 3 months after you start taking ivosidenib.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, dizziness, cough, trouble breathing, swelling, rapid weight gain, rash, or decreased urination.
Before taking this medicine
You should not use ivosidenib if you are allergic to it.
Tell your doctor if you have ever had:
heart disease;
long QT syndrome (in you or a family member);
nerve problems;
an electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood);
cirrhosis or other liver disease; or
kidney disease (or if you are on dialysis).
May harm an unborn baby. Use birth control and tell your doctor if you become pregnant.
Ivosidenib can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.
Pregnancy may be less likely to occur while the mother or the fath...
