Lifitegrast
Class: Anti-inflammatory Agents, Miscellaneous
Chemical Name: (2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid
Molecular Formula: C29H24Cl2N2O7S
CAS Number: 1025967-78-5
Brands: Xiidra
Introduction
Anti-inflammatory agent; integrin lymphocyte function-associated antigen-1 (LFA-1) inhibitor.
Uses for Lifitegrast
Dry Eye Disease
Management of dry eye disease (also known as keratoconjunctivitis sicca).
Lifitegrast Dosage and Administration
Administration
Ophthalmic Administration
Apply topically to the eye as an ophthalmic solution. For topical ophthalmic use only.
Remove contact lenses prior to administration; may reinsert lenses 15 minutes after administration.
Avoid eye injury or contamination of the solution container. Do not touch tip of single-use container to the eye or any other surface.
Sufficient amount of solution in each single-use container for administration of 1 dose into each eye. Preservative-free solution is for single use only; discard any unused portion immediately after administration.
Dosage
Adults
Dry Eye Disease
Ophthalmic
1 drop of a 5% solution in each eye twice daily, approximately 12 hours apart.
Special Populations
No special population recommendations at this time.
Cautions for Lifitegrast
Contraindications
Manufacturer states none known.
Warnings/Precautions
Specific Populations
Pregnancy
No data available regarding use in pregnant women.
No evidence of teratogenicity in pregnant rats. Increased incidence of omphalocele in pregnant rabbits.
Lactation
Not known whether distributed into milk. No data available regarding effects on breast-fed infant or milk production.
Consider developmental and health benefits of breast-feeding along with mother's clinical need for the drug and any potential adverse effects of the drug on the infant.
Pediatric Use
Safety and efficacy not established in pediatric patients <17 years of age.
Geriatric Use
No overall differences in safety or efficacy relative to younger adults.
Common Adverse Effects
Ocular effects: Instillation site irritation, reduced visual acuity, blurred vision, conjunctival hyperemia, irritation, increased lacrimation, discharge, discomf...
